Integrin complex heatmaps
This week’s issue of Science Signaling features a Perspective by Erik Danen that discusses our recent Science Signaling Research Article.
The Perspective is also highlighted on the cover of the journal.
Archives for posts with tag: integrins
Our paper has been published in this week’s issue of Science Signaling.
Our work describes a methodology for the isolation and proteomic analysis of ligand-induced integrin adhesion complexes. Using this approach, we identified regulator of chromosome condensation 2 (RCC2) as a component of fibronectin-activated integrin signalling pathways that regulate cell migration.
Science Signaling cover, 2009, vol. 2 (no. 87)
A press release has been issued in advance of publication of our paper in Science Signaling.
The way the cells in our bodies communicate with each other and their environment is of fundamental importance to human biology. This complex process of cellular crosstalk, or signalling, must be precisely controlled. When signalling goes wrong, it can lead to disease. We have developed a technique to examine how receptors on the surface of cells pass information to the hundreds of proteins inside the cell that form the signalling machinery. Uniquely, our findings enable scientists to look at the hundreds of components of cell signalling at the same time. This will provide a completely new insight into how our bodies work and opens up new avenues for drug development and testing.
Adam Byron 