press release has been issued in advance of publication of our paper in Science Signaling.

The way the cells in our bodies communicate with each other and their environment is of fundamental importance to human biology. This complex process of cellular crosstalk, or signalling, must be precisely controlled. When signalling goes wrong, it can lead to disease. We have developed a technique to examine how receptors on the surface of cells pass information to the hundreds of proteins inside the cell that form the signalling machinery. Uniquely, our findings enable scientists to look at the hundreds of components of cell signalling at the same time. This will provide a completely new insight into how our bodies work and opens up new avenues for drug development and testing.