Archives for category: Press

Cells of the body are constantly communicating with their surroundings. This integration of cells with their local environment is mediated by proteins on the surface of cells called integrin adhesion receptors. But how these proteins precisely control normal cellular functions is not well understood. In fact, it turns out to be extremely complex.

In new work, this complexity of cellular signalling is analysed. Distilling down the deluge of data allowed us to discover a key collection of components that congregate at sites of cell adhesion. These proteins play important roles in allowing cells to sense their surroundings, move and survive. When these processes go wrong, diseases like cancer can develop.

Our work is also featured on the cover of this month’s issue of Nature Cell Biology, with an image by Ed Horton showing all the proteins we analysed. See if you can spot your favourite adhesion protein!

Nature Cell Biology cover, 2015, vol. 17 (no. 12) // Image by Ed Horton

Nature Cell Biology cover, 2015, vol. 17 (no. 12)

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A press release has been issued by Cancer Research UK about a paper from the University of Edinburgh on the protein focal adhesion kinase (or FAK) and how it modulates the immune system in cancer to allow tumour cells to grow.

A class of experimental drug treatments already in clinical trials could also help the body’s immune system to fight cancer.

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Having an effective online presence is becoming a vital part of professional life. Scientific careers are no exception, explains Angela Hopp in this month’s edition of ASBMB Today.

Published in the membership magazine of the American Society for Biochemistry and Molecular Biology, the editorial highlights reasons to showcase one’s work on the web and why scientists reap benefits from engaging in online discourse.

I’m convinced that scientists can benefit from creating and maintaining online personas.
— Angela Hopp, Editor, ASBMB Today

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The October issue of UniLife, the University of Manchester’s monthly magazine, features an article reporting our recent Science Signaling Research Article.

UniLife aims to highlight the progress the University is making towards achieving its ambitious 2015 vision.

Adhesion complex network // Image by Adam Byron

press release has been issued in advance of publication of our paper in Science Signaling.

The way the cells in our bodies communicate with each other and their environment is of fundamental importance to human biology. This complex process of cellular crosstalk, or signalling, must be precisely controlled. When signalling goes wrong, it can lead to disease. We have developed a technique to examine how receptors on the surface of cells pass information to the hundreds of proteins inside the cell that form the signalling machinery. Uniquely, our findings enable scientists to look at the hundreds of components of cell signalling at the same time. This will provide a completely new insight into how our bodies work and opens up new avenues for drug development and testing.