Work by Mark Bass and others has been published in this week’s issue of Developmental Cell.
This study investigates the cellular mechanisms that are required for tissue repair. To heal a wound, cells called fibroblasts must migrate through the surrounding extracellular matrix to the site of damage. Once at the damaged tissue, fibroblasts contract the wound and begin the healing process. This paper identifies how cells can detect and respond efficiently to tissue damage.
My article on the architecture of integrin adhesion sites has been published in this week’s issue of Science Signaling. This Focus Issue of Science Signaling highlights processes in cell signalling that enable cells to move efficiently and appropriately.
My Presentation on the proteomic analysis of integrin complexes has been published in this week’s issue of Science Signaling. There is an accompanying slideshow of the presentation.
I presented the talk at the 6th British Society for Proteome Research (BSPR)–European Bioinformatics Institute (EBI) Meeting, entitled “Multiscale Proteomics: From Cells to Organisms,” in Cambridge, UK. I was thrilled to be awarded the 2009 BSPR Early Stage Investigator Award at the conference.
Our Primer on adhesion signalling complexes has been published in the current issue of Current Biology.
The article provides an accesible overview of the role of extracellular-matrix receptors and their associated protein complexes and signalling networks in the control of cell adhesion and migration. We focus on the molecular complexity of adhesion signalling complexes and mechanisms of their regulation, which impact on many aspects of cell behaviour in health and disease.
Our recent Science Signaling Research Article is featured in Signaling Breakthroughs of the Year published in the current issue of Science Signaling.
The Signaling Breakthroughs of the Year Editorial Guide is an annual feature that shortlists the most important cell signalling advances of the previous year. Science Signaling Chief Scientific Editor Michael Yaffe (Massachusetts Institute of Technology, USA) highlighted our proteomic analysis of integrin signalling complexes as a notable contribution to the development of methodologies that enable network-level analyses of signal transduction, an important theme of this year’s selected signalling breakthroughs.
I am also pleased to have created one of the figures used in the Editorial Guide.
Adam Byron 