Archives for posts with tag: signal transduction

Our Primer on adhesion signalling complexes has been published in the current issue of Current Biology.

The article provides an accesible overview of the role of extracellular-matrix receptors and their associated protein complexes and signalling networks in the control of cell adhesion and migration. We focus on the molecular complexity of adhesion signalling complexes and mechanisms of their regulation, which impact on many aspects of cell behaviour in health and disease.

Adhesion complex interaction network // Image by Adam Byron

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Four of my images have been shortlisted for the European Proteomics Association (EuPA2010 Photography and Graphic Arts Contest. The images attempt to illustrate the complexity of cell signalling, and they represent different aspects of my work on the proteomic analysis of integrin adhesion complexes in Martin Humphries’s lab.

Citrus Gels

Citrus Gels

You can view my shortlisted entries (#16-#19, inclusive) here, where you also have the opportunity to vote for your favourite!

Our recent Science Signaling Research Article is featured in Signaling Breakthroughs of the Year published in the current issue of Science Signaling.

The Signaling Breakthroughs of the Year Editorial Guide is an annual feature that shortlists the most important cell signalling advances of the previous year. Science Signaling Chief Scientific Editor Michael Yaffe (Massachusetts Institute of Technology, USA) highlighted our proteomic analysis of integrin signalling complexes as a notable contribution to the development of methodologies that enable network-level analyses of signal transduction, an important theme of this year’s selected signalling breakthroughs.

I am also pleased to have created one of the figures used in the Editorial Guide.

Adhesion complex network

Adhesion complex network

Our recent Science Signaling Research Article is featured in the current Top 10 cell biology papers evaluated on Faculty of 1000 Biology.

The Top 10 are generated using papers added to Faculty of 1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor, which incorporates both the number of times a paper has been evaluated and the ratings it has received.

In addition to the evaluation by Herbert Schiller and Reinhard Fässler (Max Planck Gesellschaft, Germany), our article has now also been selected and evaluated by Alexey Belkin (University of Maryland, MD, USA).

 

 

 

 

Work by Paul Mould and others has been published in today’s issue of Biochemical Journal.

Targeting ligand-binding sites in integrins // Image by Adam Byron

This study shows that zebrafish α5 integrins do not bind human fibronectin or human α5β1 antagonists, the latter of which have therapeutic potential as anti-angiogenic agents in cancer and diseases of the eye. Exploiting the ligand-binding features of zebrafish α5 integrin, a gain-of-function mutagenesis approach was used to identify the regions of the α5 subunit required for interactions with human fibronectin ligand or human α5β1 antagonists. These results will aid the development of more potent α5β1 antagonists and of in vivo models suitable for drug screening or discovery.

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