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Seminar presentation at the University of Warwick

26 November 2009 //
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I am pleased to have been invited to present a seminar at the Department of Biological Sciences, University of Warwick, UK. The seminar will cover my current work in the laboratory of Professor Martin Humphries (University of Manchester, UK), and it is titled “Analysing the complexity of cell adhesion: A proteomic approach.”

I completed my undergraduate degree at Warwick in 2004 so am really looking forward to seeing how the department has changed. Indeed, I was asked to present this seminar by Professor Lynne Roberts who was my supervisor for my final-year undergraduate research project.

The seminar is at 3pm tomorrow (27 November 2009) on Gibbet Hill campus and is part of the Genes & Development Research Interest Group seminar series.

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Categories Communication, Research, Science, Seminar

Paper in Cell Biology Top 10 on Faculty of 1000

17 November 2009 //
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Adhesion complex network

Adhesion complex network

Our recent Science Signaling Research Article is featured in the current Top 10 cell biology papers evaluated on Faculty of 1000 Biology.

The Top 10 are generated using papers added to Faculty of 1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor, which incorporates both the number of times a paper has been evaluated and the ratings it has received.

In addition to the evaluation by Herbert Schiller and Reinhard Fässler (Max Planck Gesellschaft, Germany), our article has now also been selected and evaluated by Alexey Belkin (University of Maryland, MD, USA).

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Categories Communication, Publication, Research, Science

Review published in Journal of Cell Science

15 November 2009 //
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Journal of Cell Science poster concept art

Journal of Cell Science poster concept art

Our review on anti-integrin antibodies has been published in today’s issue of Journal of Cell Science.

The Cell Science at a Glance article provides an overview of the mechanisms of antibody regulation of integrin adhesion receptors. The accompanying poster catalogues the best-characterised examples of function-regulating and non-functional antibodies. This review provides a resource for researchers to assess key reagents used in the study of integrin-mediated cell adhesion.

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Paper published in Biochemical Journal

11 November 2009 //
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Work by Paul Mould and others has been published in today’s issue of Biochemical Journal.

Targeting ligand-binding sites in integrins // Image by Adam Byron

This study shows that zebrafish α5 integrins do not bind human fibronectin or human α5β1 antagonists, the latter of which have therapeutic potential as anti-angiogenic agents in cancer and diseases of the eye. Exploiting the ligand-binding features of zebrafish α5 integrin, a gain-of-function mutagenesis approach was used to identify the regions of the α5 subunit required for interactions with human fibronectin ligand or human α5β1 antagonists. These results will aid the development of more potent α5β1 antagonists and of in vivo models suitable for drug screening or discovery.

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Paper evaluated on Faculty 1000 Biology

16 October 2009 //
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Adhesion complex network

Adhesion complex network

Our recent Science Signaling Research Article has been selected and evaluated by Herbert Schiller and Reinhard Fässler on Faculty of 1000 Biology.

Faculty of 1000 Biology is a literature-awareness tool that highlights and reviews the most interesting papers published in the biological sciences, based on the recommendations of a faculty of over 2300 selected leading researchers.

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Categories Communication, Publication, Research, Science
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